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For the searching of antibiotics in the mushroom, we studied on the screening of antiyeast and antifungal components. The powder of fruiting body of each mushroom was extracted with petroleum ether, 80% ethanol, and distilled water in that order, respectively. The antifungal activity of each extract from 32 different mushrooms were tested. The petroleum ether or ethanol extracts from fruiting bodies of Boletus aurtpes, Leccinum extremiorientale, Gomphus flocoosus, Phaeolus schweinitzii, Pycnoporus cinnabarinus and Marasmius maximus showed antiyeast activities. The ethanol extract of Gyrophora esculenta showed an antiyeast activity against Cryptococcus neoformans, and its minimal inhibitory concentration (MIC) was 600 ㎍/㎖. The petroleum ether or ethanol extracts from fruiting bodies of Amanita citrina, Leccinum extremiorientale, Gomphus floccosus, Phaeolus schweinitzii, Pycnoporus cinnabarinus, Marasmius maximus and Gyrophora esculenta showed antifungal activities. The ethanol extract of Gomphus floccoscus showed an antifungal activity against Microsporum hypseum, and its MIC was 1,000 ㎍/㎖. The ethanol extract of Gyrophora esculenta showed antifungal activities against Trichophyton mentagrophytes, Microsporum gypseum and Pyriculoria oryzae, and theirs MIC were 300 ㎍/㎖, 600 ㎍/㎖ and 600 ㎍/㎖, respectively. The petroleum ether extract of Gyrophrora esculenta also showed an antifungal activity against Microsporum gypseum, and its M1C was 300 ㎍/㎖.
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